An integrated molecular profile of endometrioid ovarian cancer
نویسندگان
چکیده
منابع مشابه
Novel molecular subtypes of serous and endometrioid ovarian cancer linked to clinical outcome.
PURPOSE The study aim to identify novel molecular subtypes of ovarian cancer by gene expression profiling with linkage to clinical and pathologic features. EXPERIMENTAL DESIGN Microarray gene expression profiling was done on 285 serous and endometrioid tumors of the ovary, peritoneum, and fallopian tube. K-means clustering was applied to identify robust molecular subtypes. Statistical analysi...
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Ovarian carcinoma is the leading cause of gynecological malignancy, with the serous subtype being the most commonly presented subtype. Recent studies have demonstrated that grade does not yield significant prognostic information, independent of TNM staging. As such, several different grading systems have been proposed to reveal morphological characteristics of these tumors, however each yield d...
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متن کاملHuman Cancer Biology Functional Analysis ofGenes inRegionsCommonlyAmplified in High-Grade Serous and Endometrioid Ovarian Cancer
Purpose: Ovarian cancer has the highest mortality rate of all the gynecologic malignancies and is responsible for approximately 140,000 deaths annually worldwide. Copy number amplification is frequently associated with the activation of oncogenic drivers in this tumor type, but their cytogenetic complexity and heterogeneity has made it difficult to determine which gene(s) within an amplicon rep...
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PURPOSE Epithelial ovarian carcinogenesis may occur de novo on the surface of ovarian mesothelial epithelial cells or from cells originating in other organs. Foreign Müllerian cell intrusion into the ovarian environment has been hypothesized to explain the latter scenario. In this study, MALDI MS profiling technology was used to provide molecular insights regarding these potentially different m...
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ژورنال
عنوان ژورنال: Gynecologic Oncology
سال: 2020
ISSN: 0090-8258
DOI: 10.1016/j.ygyno.2020.02.011